Nuberol Forte Tablets (paracetamol BP 650 mg + Orphenadrine Citrate BP 50 mg)

Nuberol Forte Tablets

(paracetamol BP 650 mg + Orphenadrine Citrate BP 50 mg)

BRIEF PRESCPIBUNG INFORMATION

PROPERTIES
Nuberol is a muscle relaxant with analgesic.

PRESENTATION AND COMPOSITION
Nuberol is white round shaped, engraved 'SEARLE' on one side each tablet contains Paracetamol BP 450mg and Orphenadrine Citrate BP 35mg.

Nuberol Forte is white, oblong scored tablets stamped stamped searle on one side each containing Paracetamol BP 650mg and Orphenadrine Citrate BP 50mg.

Pharmacology:
The combined analgesic effect of Paracetamol and muscle relaxant action of Orphenadrine Citrate provides in-depth relief from pain associated with skeletal muscle spasm.

Paracetamol possess analgesic and antipyrrtic action similar to those of the salicylates.

Analgesia is mediated peripherally and also centrally.

Paracetamol is a synthetic derivative of p-aminophenol with analgesic and antipyretic activity but on anti-inflammatory action. Its plasma half-life is about 2 hours. It is extensively metabolized in the liver and subsequently excreted in the urine.

Orphenadrine Citrate is an orally effective muscle relaxan. The mode of therapeutic action has not been clearly identified, but may be related to its analgesic properties. Orphenadrine citrate does not directly relax tense muscles in man. Orphenadrine citrate also possesses anti-cholinergic actions. Muscle relaxation is not due to a direct action on the muscle itself; rather the site of ection of Orphenadrine citrate is contral. Orphenadrine is readily absorbed from the gastro-intesinal tract and is almost completely metabolized to at least 8 metablites.

It is mainly excreted in the urine as metabolised and unchanged drug.

Indications:
For the relief of painful skeletal muscle spasm associated with chronic low back pain, spranins, strains, prolapsed intervertebbral disc, muscle injury, non-articular rheumatism, and tension headache, dysmenorrheal and other acute or chronic painful muscular conditions.

Contraindication:

Paracetamol:
Hypersensitivy to paracetamol, Repeated administration is contraindicated in patients with hepatic insufficientcy.

Orphenadrine citrate:
It is contraindicated in patients hypersensitive to Orphenadrine citrate. Orphenadrine should not be given to patientsvof myasthenia gravis, glaucona, urinary retention or lactating woman.

Dosage and Administration:

Nuberol:    Adults   : 1-2 tablet 3-4 times/day
                   Children : Not recommended.

Nuberol Fort:  Adults  : 1 tablet twice daily
                        Children : Not recommended.

Overdosage:

In overdosage Paracetamol is dangerously hepatotoxic; potentially falal hepatic necrosis can occur after ingestion of as little as a single dose of 10-15 g. Signs of mild gastrointestinal irritation are commonly followed 2 day later by anorexia, nausea, malaise, abdominal pain, progressive evidence of liver failure and, ultimately, hepatic come. Either methionone or ecetylcysteine may be used as a specific antidote. Fluid and electrolyte balance must be maintained and ventilation must be assisted when respiration is depressed.

Orphenadrine is toxic when overdosed and typically induces Anti-cholinergic effects.