Normitab Tablets
(Atenolol Tabler USP)
COMPOSITION:
each film coated tablet contains:
Atenolol USP... 25mg, 50mg or 100mg.
USP specs.
INDICATION:
Management of hypertension, angina pectoris, cardiac dysrhythmias and myocardial infarction. Early intervention in the acute phase and long-term prophylaxis after recovery from myocardial infarction.
PHARMACOLOGICAL PROPERTIES:
pharmacodynamic properties: Atenolol is a β-blocker, which is β-selective, (i.e.acts preferentially on β-adrenergic receptors in the heart). Selectively decreases with increasing dose. Atenolol is without intrinsic sympathomimetic and membranestabilizing activities and as with other β-blockers, has negative inotropic effects (and is therefore contra-indicated in uncontrolled heart failure). As with other β-blockers, the mode of action of Atenolol in tha treatment of hypertension is unclear. It is probably the action of Atenolol in reducing cardiac rate and contractilit, which makes its effective in eliminating, or reducing the symptoms of parients with angina.
Pharmacokinetic Properties:
Absorption: Absorption of Atenolol following oral dosing is consistent but incomplete (approximately 40-50%) with peak plasma concentrations occurring 2-4 hours after dosing. The bioavailability is decreased by 20% when taken with food. There is a linear relationship between dosage and plasma concentration. The intersubject variability in AUC and Cmax is about 30-40%. There is no signiflcant hepatic metabolism of Atenolol an more than 90% of that absorbed reaches the systemic circulation unaltered.
Distribution: Atenolol penetrates tissues poorly due to its low lipid solubility and its concentration in brain tissue is low. The volume of distribution is 50 to 75 L. The protein binding is low (approximately 3%). Most of an absorbed dose (85-100%) is excreted unchanged via the urine.
Eliminating: This clearance is about 6L/h and the helf-little is about 6 to 9 hours. in elderly patients, clearance is decreased and elimination half-life increased. Thec clearnce is correlated renal function and the elimination is prolonged in patients with renal impairment. Impaired liver function dose not influence the phamacokinetics of Atenolol.
DOSAGE & ADMINISTRATION:
Adults: Hypertension: Most patients will respond to 100mg daily as single dose. The effect will be fully established in 1-2 weeks. A further reduction in blood pressure takes place by combining with other anti-hypertensive drugs. Simultaneously administered diuretic is highly effective and best suited anti hypertensive therapy.
Angina: Most patients with angina will respond to 100mg daliy in single or divided doses.
(Atenolol Tabler USP)
COMPOSITION:
each film coated tablet contains:
Atenolol USP... 25mg, 50mg or 100mg.
USP specs.
INDICATION:
Management of hypertension, angina pectoris, cardiac dysrhythmias and myocardial infarction. Early intervention in the acute phase and long-term prophylaxis after recovery from myocardial infarction.
PHARMACOLOGICAL PROPERTIES:
pharmacodynamic properties: Atenolol is a β-blocker, which is β-selective, (i.e.acts preferentially on β-adrenergic receptors in the heart). Selectively decreases with increasing dose. Atenolol is without intrinsic sympathomimetic and membranestabilizing activities and as with other β-blockers, has negative inotropic effects (and is therefore contra-indicated in uncontrolled heart failure). As with other β-blockers, the mode of action of Atenolol in tha treatment of hypertension is unclear. It is probably the action of Atenolol in reducing cardiac rate and contractilit, which makes its effective in eliminating, or reducing the symptoms of parients with angina.
Pharmacokinetic Properties:
Absorption: Absorption of Atenolol following oral dosing is consistent but incomplete (approximately 40-50%) with peak plasma concentrations occurring 2-4 hours after dosing. The bioavailability is decreased by 20% when taken with food. There is a linear relationship between dosage and plasma concentration. The intersubject variability in AUC and Cmax is about 30-40%. There is no signiflcant hepatic metabolism of Atenolol an more than 90% of that absorbed reaches the systemic circulation unaltered.
Distribution: Atenolol penetrates tissues poorly due to its low lipid solubility and its concentration in brain tissue is low. The volume of distribution is 50 to 75 L. The protein binding is low (approximately 3%). Most of an absorbed dose (85-100%) is excreted unchanged via the urine.
Eliminating: This clearance is about 6L/h and the helf-little is about 6 to 9 hours. in elderly patients, clearance is decreased and elimination half-life increased. Thec clearnce is correlated renal function and the elimination is prolonged in patients with renal impairment. Impaired liver function dose not influence the phamacokinetics of Atenolol.
DOSAGE & ADMINISTRATION:
Adults: Hypertension: Most patients will respond to 100mg daily as single dose. The effect will be fully established in 1-2 weeks. A further reduction in blood pressure takes place by combining with other anti-hypertensive drugs. Simultaneously administered diuretic is highly effective and best suited anti hypertensive therapy.
Angina: Most patients with angina will respond to 100mg daliy in single or divided doses.
Normitab Tablets
Reviewed by Athar
on
00:26
Rating:
Reviewed by Athar
on
00:26
Rating:
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